The A41 from Whitchurch through to Malpas will be closed on Friday night for a maximum of five days.
The road closure, announced by Cheshire West and Chester Council, will be for northbound traffic only, with the road closed from 7pm until 6am the following day.
However, it is believed the work is only expected to last for one night.
A diversion through the A49 and the A534 will be in place before rejoining the A41 at Broxton.
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